Perry was one of three cabinet members who was overseeing the Ukraine portfolio after it was transferred away from career staff.
Energy Secretary Rick Perry told President Donald Trump on Thursday that he intends to leave his post.
The timing of his departure, first reported by Bloomberg, was not immediately clear.
Multiple representatives of the Department of Energy did not immediately respond to a request for comment.
Perry, formerly the governor of Texas, had largely avoided headlines since joining the Trump administration in 2017. But in recent weeks he became entangled in the Democratic-led impeachment probe into Trump’s actions involving Ukraine.